Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma
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چکیده
منابع مشابه
Multicentric malignant lymphoma in a pallid bat.
A 2.5-year-old, female pallid bat (Antrozous pallidus) was captured in Oregon (USA) in 1990 and later died in 1992. At the time of death, abdominal distension due to ascites, splenomegaly, and hepatomegaly, and a cheek mass were noted. Based on histologic examination of these tissues, a diagnosis of multicentric lymphoma was made. Retroviral particles were not found on electron microscopic exam...
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A 59-year-old white woman, SC, after being treated for pneumonia, presented with an increase in the size of lymph nodes. The immunohistochemical examination diagnosed histiocytic sarcoma. Relapse occurred 12 months after starting chemotherapy. The patient evolved with febrile neutropenia, septic shock and death.
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It is generally accepted that the outcome of oral malignant melanoma is worse than that of cutaneous and systemic head and neck melanoma. The five-year survival reported in the literature for oral melanomas varies from 0 20 % (Liversedge, 1975, Rapidis et al., 2003, Rapini et al., 1985), whereas the overall survival for head and neck melanomas ranges between 20 and 48 % (Guzzo et al., 1993, Pat...
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Response assessment in lymphoma relies on imaging scans that do not capture biologic processes at the molecular level. Monitoring circulating tumor DNA (ctDNA) with next-generation sequencing-based assays can detect recurrent disease prior to scans and "liquid biopsies" for somatic mutations address tumor heterogeneity, clonal evolution, and mechanisms of resistance to guide precision treatment...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-020-80332-y